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I have had many problems (one being that it took me a lot of time for my body to get used to it) with this product. The worst side effect has been the onset of diabetes which this product is responsible for. The question I had of my cardiologist is why in the world would he prescribe it to a high risk candidate like me -- I am Hispanic, in my 50s when it was prescribed. I informed my PA of this after my last crisis and she is looking into prescribing a different product (one given at the hospital) but this after a few years on Toprol. I figure that without the change from this medicine I don't stand a chance of reversing my diabetic condition.
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I have Angina and over the past year began a regime of Bayer (or Bufferin) starting at 500mg every morning. Things got a little worse after six months and I upped my dosage to 1000mg per day. This was all self medication without medical consult (I knew what the problem was). Finally even the 1000mg a day wasn't working and I went to see the doctor. He put me on 50mg of Lopressor per day and things turned around within 2 days. The pain is gone and I can get a whole nights sleep without waking up in the middle of the morning (usually 3-4am, when the incidence of heart attack is the highest statistically) in major pain. So far so good. If you have Angina then DO see a doctor. Get the tests! After all, it's really your life your dealing with.

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Fritz Bach, director of the Immunobiology Research Center at Beth Israel Deaconess Medical Center in Boston, says the approach described by the Italian researchers would make it much easier to insert a number of human genes into pig sperm.

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Clinical trial disclosures for drugs approved by the US Food and Drug Administration fail to meet both the legal and ethical standards expected, according to research published in BMJ Open on 16 November 2015.

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