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Eventually the existing heartworms will die of old age or the dog will become healthy enough to go through the heartworm treatment.

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Great care must be taken to prevent the dog from injuring itself at this time.

The anti-cancer properties of Ivermectin are therefore not limited to direct cytotoxicity and require further investigation of its immunomodulatory potential and impact on cancer immunotherapy.

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The luteal activities of the enzymes 3beta-hydroxysteroid dehydrogenase (3beta-HSD), involved in progesterone biosynthesis, and 20alpha-hydroxysteroid dehydrogenase (20alpha-HSD), that catabolizes progesterone and reduces progesterone secretion by the corpus luteum, were evaluated after intrabursal ovarian administration of progesterone in pregnant rats that had received a luteolytic dose of prostaglandin F2alpha (PGF2alpha).

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Ivermectin may be used in horses of all ages, including mares at any stage of pregnancy and foals that are 6 to 8 weeks old.

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The clinical utility of this formulation is further suggested especially in various conditions related with luteal phase insufficiency and Bad obstetric history (BOH) or luteal phase support in ART.

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Ivermectin does not typically produce side effects at the low doses veterinarians use for heartworm prevention.

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Stem-cell-enriched CD49fhi cells amplify at dioestrus, or with exogenous progesterone, demonstrating a key role for progesterone in propelling this expansion.

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