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It does have a prophylactic, suppressive effect that helps to reduce the incidence of acute attacks and to relieve the residual pain and mild discomfort that patients with gout occasionally feel.
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In the CORP trial, colchicine as an adjunct to conventional anti-inflammatory therapy halved the recurrence rate of pericarditis at 18 months after a first episode reduced the number of recurrences, and prolonged the time to subsequent recurrence, with no significant or severe side effects.
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It is not easy to pinpoint the exact cause of gout but we do know that excessive uric acid is caused by “good living”.
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Inform patients that bone marrow depression and neuromuscular toxicity may occur; patients should seek medical attention promptly for unusual bleeding or bruising, increased infections, weakness or fatigue, muscle pain or weakness, or numbness or tingling in fingers or toes.
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Lumiracoxib 400 mg once daily is comparable to indomethacin 50 mg three times daily for the treatment of acute flares of gout.
This was followed by the report of the multicenter, double-blind Colchicine for Recurrent Pericarditis (CORP) trial and a subsequent meta-analysis supporting the use of colchicine in such patients.
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Concomitant administration of rifabutin and Clarithromycin resulted in an increase in rifabutin, and decrease in Clarithromycin serum levels together with an increased risk of uveitis.
Pseudogout may involve any joint, although the small joints in the fingers or toes are not commonly affected.
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Tamponade occurs when all cardiac chambers are compressed as a result of increased intrapericardial pressure to the point of compromising systemic venous return to the right atrium (RA).
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