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Sullivan is Professor, Department of Behavioral Health and Psychiatry, West Virginia University of Medicine, Morgantown, Virginia.

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Nociceptor pain results when tissue damage produces a stimulus that sends an electrical impulse across a pain receptor (nociceptor) by way of a nerve fiber to the central nervous system.

This tolerance contributes to the high risk of overdose during a relapse to opioid use after a period in recovery; users who do not realize they may have lost their tolerance during a period of abstinence may initially take the high dosage that they previously had used before quitting, a dosage that produces an overdose in the person who no longer has tolerance.

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Take vitamins B1 (thiamine), B12 and folate to reduce the chances of alcohol-related brain damage.

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